What is the Preparation and Stability of Calamine Suspension?
What is the Preparation and Stability of Calamine Suspension?.
Introduction:
Suspensions are solid dipersion of insoluble or sparingly-soluble drugs, in aqueous like keltrol or oily vehicles such as emulsion. Suspension are used for oral administration, external application to the skin (topical) or parenteral administration.These particles suspended into liquid medium do not dissolve but have dispersed in according to the particles size, and can settle to form to layer (drug layer/fluid medium) due to gravity(sedimentation). Due to this reason Suspension agents are used to redistribute the suspension on shaking. In order for a drug to have impact the solid particles should not be greater than micrometers to aid in dispersion and absorption within the body and to avoid in creams a gritty effect.In this experiment we looked at calamine lotion suspension in which sodium citrate (preservative) and betonies are the suspension agents. (1,2)
Method:
7.5g of calamine and 2,5g of zinc oxide was weighed and grinded in a pestle and mortar to a fine powder, 2.5ml of glycerin was added to this power mixture and grinded to a fine mixture which took roughly 2-5 minutes. The remaining residues of the glycerin within the cylinder were washed out with 6 5ml portions of water. This was transferred into a 50ml cylinder with the slurry from the mortar and made to bulk (50ml) with water. Clingfilm was used to wrap the top of the cylinder to prevent leaks while gently inverting the cylinder repeatedly until the product was homogenous. This was then placed on the bench and timer was started to record the volume of sediment and overall volume in ml. Results were tabulated.
Discussion
The results ands graph show that formula D sedimentation was the most rapid followed by formulae A It would have been expected that formula A would have the highest sedimentation rate due there not being any bentonite and sodium citrate present. Formula D is result is accurate this is due to errors. Comparing Formula B and I as both had 1.5g of one Flocculants in mixture, formula B which only contained bentonite, the sedimentation rate was slightly faster. Formula F which contained both, but bentonite is excess, this mixture had the slowest sedimentation rate A combination of the two flocculants shows to be the most effective
Conclusion
From the experiment we were able to achieve fairly good results, the results showed that bentonite and sodium citrate played a key role in the rate of sedimentation as it provided and maintained the viscosity of the suspension and the uniformity. Also we can also conclude that bentonite is also more effective that sodium citrate as a suspension agent.
References:
(1) http://pharmacy.wilkes.edu/kibbeweb/lab5.html date:14/03/11
(2) http://www.lumamericas.com/ date 14/03/11
What is the Preparation and Stability of Calamine Suspension?
Calculate the price of your order
Select your paper details and see how much our professional writing services will cost.
- Freebies
- Format
- Formatting (MLA, APA, Chicago, custom, etc.)
- Title page & bibliography
- 24/7 customer support
- Amendments to your paper when they are needed
- Chat with your writer
- 275 word/double-spaced page
- 12 point Arial/Times New Roman
- Double, single, and custom spacing
-
We care about originality
Our custom human-written papers from top essay writers are always free from plagiarism.
-
We protect your privacy
Your data and payment info stay secured every time you get our help from an essay writer.
-
You control your money
Your money is safe with us. If your plans change, you can get it sent back to your card.
How it works
-
1
You give us the detailsComplete a brief order form to tell us what kind of paper you need.
-
2
We find you a top writerOne of the best experts in your discipline starts working on your essay.
-
3
You get the paper doneEnjoy writing that meets your demands and high academic standards!
Get your own paper from top experts
Order nowPerks of our essay writing service
We offer more than just hand-crafted papers customized for you. Here are more of our greatest perks.
Frequently asked questions
Get instant answers to the questions that students ask most often.
See full FAQWhat if I’m dissatisfied with the paper I get?
The average quality score at our professional custom essay writing service is 8.5 out of 10. The high satisfaction rate is set by our Quality Control Department, which checks all papers before submission. The final check includes:- Compliance with initial order details.
- Plagiarism.
- Proper referencing.
I need an essay on the same day. Is it something you can do?
Sure. Our writing company offers a fast service with an 8-hour deadline for orders up to master’s level. Make sure to specify the deadline in the order form and our writers will write a paper within the indicated timeslot. Just proceed to submit your requirements here Once you order a custom-written essay, our managers will assign your order to the well-suited writer, who has the best skills and experience for preparing your specific assignment. You can also request one of these extra features:- Choose the Writer’s Samples option – study 3 randomly-provided pages from orders that have been written by the assigned writer.
- Request a specific writer – choose an academic writer from the dropdown list in the order’s form (optional for returning customers).
How can I be sure your writing service is not a scam?
We understand that a shade of mistrust has covered the paper writing industry, and we want to convince you of our loyalty. Apart from high-quality writing services, we offer:- The chances of students to boost writing skills in a quick and effective way.
- The opportunity to manage studies and free time in an enjoyable manner.
- The possibilities to improve overall academic performance.
Is it legal to use your professional writing service?
Yes. Custom writing help is not prohibited by any university or college. It’s a 100% legal way of getting professional assistance with paper writing. Hiring writers from an essay writing company is in many ways similar to consulting a tutor – we help you solve the writing issues at hand.How does your service work?
Our custom writing service is a reliable solution on your academic journey that will always help you if your deadline is too tight. You fill in the order form with your basic requirements for a paper: your academic level, paper type and format, the number of pages and sources, discipline, and deadline. Then, you describe the specific details of the paper you need: add the topic, write or paste the instructions, and attach files to be used, if you have them. After that, an online customer support representative chooses the best writer that specializes in your discipline and assigns him or her to complete the paper according to your requirements. When the paper is ready, we check it for plagiarism and send it to you. If you want to change something, you can request a free revision.